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Analysis of neutralizing power of anti-acid tablets Essay

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Neutralization occurs when acid and alkali are mixed together. It involves the reaction between H+ and OH-, forming salt and water. The properties of acid and alkali will be cancelled out in the process of neutralization.

In our stomach, the gastric juice inside contains concentrated HCl (at about pH2). When excessive amount of gastric juice is secreted, we will feel discomfort in stomach or even heartburn. In this case, anti-acid tablets can be used to relief the pain. The suspension of the anti-acid contain OH- which will combine with the H+ found in the HCl of the juice to form a salt and water. Thus, the excess gastric juice can be neutralized.

In this experiment, the active ingredient contents (Mg(OH)2 / Al(OH)3) of different brands of anti-acids are analyzed using volumetric analysis. Since Mg(OH)2 / Al(OH)3 is insoluble in water, we cannot determine the actual amount of OH- by simply titrating its aqueous solution against HCl(aq). Thus, we should first dissolve it in excess amount of HCl(aq) of known molarity.

Then, we should carry out back titration of the reaction mixture against NaOH of known molarity, in order to determine the amount of H+ left in the reaction mixture. In this way, we can find out the actual amount of H+ used to neutralize the OH- inside the tablets. At last, we can determine the amount of active ingredients inside the anti-acid tablets.

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Reactions involved:

Mg(OH)2(s) + 2HCl(aq) MgCl2(aq) +2H2O(l)

Al(OH)3(s) +3HCl(aq) AlCl3(aq) +3H2O(l)

NaOH(aq) +HCl(aq) NaCl(aq) + H2O(l)

Brands we have chosen:

1. ACTAL plus anti-acid tablet

Contents: Aluminium Hydroxide 200mg

Magnesium Hydroxide 150mg

Simethicone* 25mg

2. Hydrosil Tab

Contents: Aluminium Hydroxide 200mg

Magnesium Hydroxide 200mg

Simethicone 20mg

3. Maalox Plus Tab

Contents: Aluminium Hydroxide 200mg

Magnesium Hydroxide 200mg

Simethicone 25mg

4. Magsil

Contents: Aluminium Hydroxide Dried Gel 200mg

Magnesium Hydroxide 200mg

5. Fedra-Gel-S

Contents: Aluminium Hydroxide Dried Gel 200mg

Magnesium Hydroxide 200mg

Simethicone 30mg

Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to form larger bubbles in the stomach that can pass through the oesophagus easily by burping.

Some calculations involved before designing the experiment:

No of mol of OH- in one tablet: 0.2×3 + 0.2×2

26.98+(16.0+1.0)x3 24.3+(16.0+1.0)x2

= 0.014555

No of mol of H+ required: 0.014555

No of mol of HCl required: 0.014555

Since No of mol= Molarity x Volume,

Volume of HCl: No of mol

Molarity

= 0.014555

1

= 0.014555 dm3 = 14.6 cm3

? The minimum amount of 1M HCl required to dissolve all the OH- inside one anti-acid tablet is 14.6 cm3.

? The 0.1 M NaOH used should be in the range of 15 – 40 cm3.

Let x be the added amount of 1M HCl.

(x-0.0146) � 1 � 10 � 250 = 0.040 � 0.1

x = 0.1146

? The amount of 1M HCl added should be around 100cm3.

Chemicals and Apparatus required:

Chemicals required:

1. 1M HCl (aq)

2. 0.1M NaOH (aq)

3. Different brands of anti-acid tablets

4. Phenolphthalein

Apparatus required:

1. Wash bottle

2. 10 cm3 and 25cm3 Pipette

3. Pipette filler

4. Burette

5. 250cm3 Volumetric flask

6. Conical flask

7. Filter funnel

8. 250ml Beaker

9. Glass rod

10. Clamp and stand

11. White tile

12. Mortar and Pestle

Procedures:

1. Crush one tablet into powder form with pestle and mortar.

2. Transfer the crushed sample to a 250cm3 beaker.

3. Wash a 25cm3 pipette with distilled water then the 1M HCl.

4. Pour in 100cm3 of 1M HCl by the washed pipette to dissolve all crushed sample.

5. Pour the mixture into a 250cm3 volumetric flask washed with distilled water. Add distilled water into the flask until it reaches the graduation mark. Invert the flask for several times.

6. Wash a 10cm3 pipette with distilled water then diluted solution. Transfer 10cm3 of the solution into a conical flask.

7. With the use of the filter funnel, rinse the burette with distilled water and then with 0.1M NaOH.

8. Fill the burette with 0.1M NaOH. Record the initial reading of the burette.

9. Add a few drops of phenolphthalein into the conical flask.

10. Run the 0.1M NaOH into the conical flask until the solution turns from colourless to permanent pink.

11. Record the final reading of the burette.

12. Repeat the above steps several times to obtain a mean titre.

13. Repeat the whole process by using different brands of anti-acid tablets.

Calculations:

Mean titre of NaOH used: V1

No of mol of OH- used: V1 � Molarity (0.1M)

= 0.1V1

No of mol of H+ used to react with OH-: 0.1V1

No of mol of H+ left after the neutralization with the anti-acid tablet:

0.1V1 � 250 � 10 = 2.5 V1

No of mol of H+ used by the anti-acid tablet: Total no of mol of HCl used -2.5 V1

= 100 -2.5 V1

No of mol of OH- in each anti-acid = No of mol of H+ used = 100 -2.5 V1.

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Analysis of neutralizing power of anti-acid tablets. (2017, Aug 09). Retrieved from http://bestsecuritysystema.life/analysis-of-neutralizing-power-of-anti-acid-tablets-essay

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Hi, I am Sara from Studymoose

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Hi, I am Sara from Studymoose

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